This webinar is an AAOS member benefit: members attend for FREE!
Description
Background:
Extended oral prophylactic antibiotics have been increasingly used in arthroplasty with the goal of reducing the risk of prosthetic joint infection (PJI). While a reduction in the rate of PJI has been noted with extended oral antibiotic regimens in high-risk patients, no large database study has assessed infection risk after primary total hip arthroplasty among well-balanced cohorts receiving and not receiving postoperative extended oral antibiotics.
Methods:
A retrospective cohort study was conducted using a national database, TriNetX, to identify patients who underwent primary total hip arthroplasty. This cohort was stratified by oral antibiotic prescription within one day of procedure. A one-to-one propensity score matching based on age, sex, class of obesity, and medical comorbidities was conducted. Outcomes explored in this study were 90-day risk of PJI, superficial skin infection, deep skin infection, and all-cause revision.
Results:
90-day postoperative infection complications of PJI were higher in the group receiving antibiotics (hazard ratio: 1.83, P-value = 0.012). Other complications such as superficial skin infection, deep skin infection, and all-cause revision showed no statistically significant differences.
Conclusion:
This database analysis of 5,476 patients demonstrated no decrease in complications of PJI, superficial or deep skin infection, or revision at 90 days. Future randomized controlled trials are needed to evaluate the efficacy of extended oral antibiotics.
Learning Objectives
- Understand the Role of Extended Oral Antibiotics in Arthroplasty
- Analyze the Study Design and Methodology
- Evaluate the Key Findings of the Study
- Interpret the Statistical Significance of Results
- Examine the Need for Future Research
- Critically Assess the Impact on Clinical Practice
Director
Charles L. Nelson, MD, FAAOS
Faculty
Nicholas M. Hernandez, MD
Sanjay Kubsad, BS
Andrew P. Collins, MD
Suhas P. Dasari, MD
Howard A. Chanksy, MD
Navin D. Fernando, MD
The American Academy of Orthopaedic Surgeons is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. The American Academy of Orthopaedic Surgeons designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
If you are unable to attend the live webinar, you may still register to be notified upon the availability of the recorded session. Access to the recording will be granted for a duration of 2 years.